basic FUNCTION
| rapid transport of Ca2+ during excitation contraction, preventing overloading of intracellular stores during relaxation |
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involved in the regulation of osteoclasts cytosolic calcium and bone resorption |
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involved in the contractile regulation of small arteries and in the development of salt-dependent hypertension, through calcium entry |
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intimately involved in the regulation of calcium (Ca(2+)) homeostasis in many tissues including excitation-secretion coupling in pancreatic beta-cells |
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play a crucial role in ionic regulation because they are the major bidirectional system promoting the efflux and influx of Na(+) and Ca(2+) ions |
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with SLC8A3, represent novel additional molecular targets for the prosurvival action of PI3-K/Akt pathway |
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involvement in the directional Ca(2+) extrusion pathway from cells to the enamel mineralizing front |
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new physiological role for mitochondrial as the key player in glutamate-induced energy production |
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extrudes calcium from cardiac myocytes during relaxation and returns the myocardium to its resting state after excitation |
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is also the major pathway for Na+ influx into mitochondria |
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can directly act as a regulator of "activity-dependent signal transduction" mediating changes in its own expression |
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SLC8A1 and SLC8A3, but not SLC8A2, were divergently modulated during oligodendrocyte precursor cells differentiation into oligodendrocyte |
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key component of certain distinct signaling pathways that activate vascular smooth muscle contraction in response to stretch (i.e., myogenic response) and to activation of certain G-protein-coupled receptors |
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plays a major role in the cardiac contractile cycle via efflux of Ca2+ from the cardiomyocyte after its transient rise during systole |
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contribute to excitation-contraction coupling, long-term potentiation of the brain and learning, blood pressure regulation, immune response, neurotransmitter and insulin secretion |
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Na(+)/Ca(2+) exchanger-mediated Ca(2+) clearance mediated by SLC8B1 and SLC8A1 is crucial for optimizing mitochondrial function, which in turn contributes to vesicle recruitment for sustained exocytosis in pancreatic beta-cells |
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