Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CRYGS contributors: mct - updated : 25-10-2018
HGNC name crystallin, gamma S
HGNC id 2417
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ABAB pattern,structural motif characteristic of the beta-gamma crystallin superfamily
  • four greek key motifs
    • conjugated Other
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Crygs
    homolog to C.elegans Y71F9B.13B
    Homologene
    FAMILY
  • beta/gamma-crystallin family
  • crystallin superfamily
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • being a structural component of the eye lens
  • involved in epithelial cell growth and migration and may contribute to lens fibre organisation
  • contributing to the refractive index and transparency of lens
  • major human lens protein, known to undergo several age-dependent changes
  • may have a functional role related to actin, perhaps in 'shepherding' filaments to maintain the optical properties of the lens cytoplasm and normal fiber cell maturation
  • age-dependent cleavage of CRYGS generates a peptide that binds to cell membranes
    • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell shape and cell size control
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    photoreception
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • when glutathione becomes bound to gammaS-crystallin, it causes it to bind in turn to the beta-crystallin polypeptides to form a dimer
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CPC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS