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FLASH GENE
Symbol CRYGS contributors: mct - updated : 25-10-2018
HGNC name crystallin, gamma S
HGNC id 2417
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyelens  predominantly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ABAB pattern,structural motif characteristic of the beta-gamma crystallin superfamily
  • four greek key motifs
  • conjugated Other
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Crygs
    homolog to C.elegans Y71F9B.13B
    Homologene
    FAMILY
  • beta/gamma-crystallin family
  • crystallin superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • being a structural component of the eye lens
  • involved in epithelial cell growth and migration and may contribute to lens fibre organisation
  • contributing to the refractive index and transparency of lens
  • major human lens protein, known to undergo several age-dependent changes
  • may have a functional role related to actin, perhaps in 'shepherding' filaments to maintain the optical properties of the lens cytoplasm and normal fiber cell maturation
  • age-dependent cleavage of CRYGS generates a peptide that binds to cell membranes
  • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell shape and cell size control
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    photoreception
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • when glutathione becomes bound to gammaS-crystallin, it causes it to bind in turn to the beta-crystallin polypeptides to form a dimer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CPC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS