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FLASH GENE

Symbol

CRYGS

contributors: mct - updated : 25-10-2018

HGNC name	crystallin, gamma S
HGNC id	2417

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye lens     predominantly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two ABAB pattern,structural motif characteristic of the beta-gamma crystallin superfamily
	four greek key motifs

conjugated

Other

mono polymer

monomer

HOMOLOGY

interspecies	ortholog to murine Crygs
	homolog to C.elegans Y71F9B.13B

Homologene

FAMILY	beta/gamma-crystallin family
	crystallin superfamily

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	being a structural component of the eye lens
	involved in epithelial cell growth and migration and may contribute to lens fibre organisation
	contributing to the refractive index and transparency of lens
	major human lens protein, known to undergo several age-dependent changes
	may have a functional role related to actin, perhaps in 'shepherding' filaments to maintain the optical properties of the lens cytoplasm and normal fiber cell maturation
	age-dependent cleavage of CRYGS generates a peptide that binds to cell membranes

CELLULAR PROCESS	cell life, proliferation/growth
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	cell shape and cell size control

PATHWAY

metabolism

signaling

sensory transduction/vision

photoreception

a component

INTERACTION

DNA

RNA

small molecule

protein

when glutathione becomes bound to gammaS-crystallin, it causes it to bind in turn to the beta-crystallin polypeptides to form a dimer

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CPC

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS