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FLASH GENE
Symbol CRYGS contributors: mct - updated : 25-10-2018
HGNC name crystallin, gamma S
HGNC id 2417
Corresponding disease
CPC progressive polymorphic cortical cataract
Location 3q27.3      Physical location : 186.256.232 - 186.262.167
Synonym name
  • crystallin,gamma polypeptide 8
  • crystallin, gamma 8
  • Synonym symbol(s) CRYG8, CTRCT20
    DNA
    TYPE functioning gene
    STRUCTURE 6.01 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 700 - 178 - 2000 10837510
    3 polyA site 919 - 178 - 2000 10837510
    - - - - - several, non lens tissues 2000 10837510
    alternative splicing into sequences of intron 1
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeyelens  predominantly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two ABAB pattern,structural motif characteristic of the beta-gamma crystallin superfamily
  • four greek key motifs
  • conjugated Other
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Crygs
    homolog to C.elegans Y71F9B.13B
    Homologene
    FAMILY
  • beta/gamma-crystallin family
  • crystallin superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • being a structural component of the eye lens
  • involved in epithelial cell growth and migration and may contribute to lens fibre organisation
  • contributing to the refractive index and transparency of lens
  • major human lens protein, known to undergo several age-dependent changes
  • may have a functional role related to actin, perhaps in 'shepherding' filaments to maintain the optical properties of the lens cytoplasm and normal fiber cell maturation
  • age-dependent cleavage of CRYGS generates a peptide that binds to cell membranes
  • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell shape and cell size control
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    photoreception
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • when glutathione becomes bound to gammaS-crystallin, it causes it to bind in turn to the beta-crystallin polypeptides to form a dimer
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CPC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS