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FLASH GENE

Symbol

IDE

contributors: mct/npt - updated : 12-10-2016

HGNC name	insulin-degrading enzyme
HGNC id	5381

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function reduction in MME and IDE activity is not the primary cause of APP accumulation in Alzheimer disease, but rather a late-stage phenomenon secondary to neurodegeneration

Susceptibility

to type 2 diabetes

Variant & Polymorphism other	polymorphisms increasing the risk of type 2 diabetes
	association of IDE polymorphisms with T2DM (Rudovich 2009)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   inhibition of IDE may represent an approach to improve glucose metabolism in human type 2 diabetes, without inducing amyloid deposition and its deleterious effects

ANIMAL & CELL MODELS