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FLASH GENE

Symbol

TFF1

contributors: mct - updated : 09-11-2015

HGNC name	trefoil factor 1
HGNC id	11755

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in primary gastric cancer tumoral       loss of function in breast (tract, digestive) cancer, and some digestive tumors (stomach, pancreas, biliary tract) tumoral     --low   in gastric tumors in which tumors exhibited overexpression of CEBPB tumoral     --over   by hypomethylation of the promoter/enhancer region, significantly lower in prostate carcinoma compared to benign prostatic hyperplasia tumoral     --low   TFF1 expression is significantly downregulated in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	overexpression and promoter hypomethylation of trefoil factors may serve as biomarkers in prostate carcinoma
Therapy target
	System Type Disorder Pubmed cancer reproductive breast Functional antagonism of TFF1 can therefore be considered as a novel therapeutic strategy for mammary carcinoma

ANIMAL & CELL MODELS