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FLASH GENE

Symbol

CD81

contributors: mct - updated : 15-11-2014

HGNC name	CD81 molecule
HGNC id	1701

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a new functional domain of CD81 that is essential for virus entry
	C-terminal domain interacting with the small GTPase RAC1

HOMOLOGY

Homologene

FAMILY

tetraspanin (TM4SF) family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	target of an antiproliferative antibody
	implicated in a variety of complex cell processes including cell fusion
	with CD63 and CD9 are all involved in multinucleated giant cells formation, but play distinct roles
	specifically required for the formation of lamellipodia in migrating dendritic cells
	essential for the formation of membrane protrusions and regulates RAC1-activation in adhesion-dependent immune cell migration
	interacts with the T cell receptor to suppress signaling
	normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81
	HHEX binding to CD81 keeps it outside the nucleus
	controls the organization of the immune synapse (IS) and T cell activation
	important role of CD81 in the molecular organization and dynamics of the IS architecture that sets the signaling threshold in T cell activation
	role for CD81 in regulating hepatoma mobility and it is a tumour promoter

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	constituent of integral membrane protein
	CD19 functions in a complex with CD21, CD81, and CD225 to signal with the B cell receptor upon antigen recognition
	IFITM5 forms a complex with FKBP11-CD81-PTGFRN

INTERACTION

DNA

RNA

small molecule

protein	RNF128 bound to the luminal/extracellular portion of both CD151 and the related tetraspanin CD81 using its PA domain, which promoted ubiquitination of cytosolic lysine residues
	role of MARCH8 and MARCH4 in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins
	IFITM5 associates with CD81 through FKBP11
	CD81-RAC1 interaction was direct and independent of RAC1 activation status
	binding partner for GPC3, and its expression and co-localization with GPC3 increased at the end of hepatocyte proliferation
	CD81-HHEX binding (when GPC3 binds to CD81, CD81-HHEX binding decreases, resulting in nuclear translocation of HHEX and transcriptional repression)
	stimulates melanoma cell motility by inducing MMP14 expression through the AKT1-dependent Sp1 activation signaling pathway, leading to increased melanoma invasion and metastasis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CVID6

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   CD81 defect disrupts CD19 complex formation and leads to antibody deficiency

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS