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FLASH GENE
Symbol CD81 contributors: mct - updated : 15-11-2014
HGNC name CD81 molecule
HGNC id 1701
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a new functional domain of CD81 that is essential for virus entry
  • C-terminal domain interacting with the small GTPase RAC1
    • HOMOLOGY
    Homologene
    FAMILY
  • tetraspanin (TM4SF) family
    • CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • target of an antiproliferative antibody
  • implicated in a variety of complex cell processes including cell fusion
  • with CD63 and CD9 are all involved in multinucleated giant cells formation, but play distinct roles
  • specifically required for the formation of lamellipodia in migrating dendritic cells
  • essential for the formation of membrane protrusions and regulates RAC1-activation in adhesion-dependent immune cell migration
  • interacts with the T cell receptor to suppress signaling
  • normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81
  • HHEX binding to CD81 keeps it outside the nucleus
  • controls the organization of the immune synapse (IS) and T cell activation
  • important role of CD81 in the molecular organization and dynamics of the IS architecture that sets the signaling threshold in T cell activation
  • role for CD81 in regulating hepatoma mobility and it is a tumour promoter
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of integral membrane protein
  • CD19 functions in a complex with CD21, CD81, and CD225 to signal with the B cell receptor upon antigen recognition
  • IFITM5 forms a complex with FKBP11-CD81-PTGFRN
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RNF128 bound to the luminal/extracellular portion of both CD151 and the related tetraspanin CD81 using its PA domain, which promoted ubiquitination of cytosolic lysine residues
  • role of MARCH8 and MARCH4 in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins
  • IFITM5 associates with CD81 through FKBP11
  • CD81-RAC1 interaction was direct and independent of RAC1 activation status
  • binding partner for GPC3, and its expression and co-localization with GPC3 increased at the end of hepatocyte proliferation
  • CD81-HHEX binding (when GPC3 binds to CD81, CD81-HHEX binding decreases, resulting in nuclear translocation of HHEX and transcriptional repression)
  • stimulates melanoma cell motility by inducing MMP14 expression through the AKT1-dependent Sp1 activation signaling pathway, leading to increased melanoma invasion and metastasis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CVID6
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    CD81 defect disrupts CD19 complex formation and leads to antibody deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS