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FLASH GENE
Symbol AVP contributors: mct - updated : 02-04-2016
HGNC name arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal)
HGNC id 894
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Copeptin, is the C-terminal part of the vasopressin prohormone
    • isoforms Precursor arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin
    HOMOLOGY
    Homologene
    FAMILY vasopressin/oxytocin family
    CATEGORY secretory , signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • neurosecretory vesicles
    • basic FUNCTION
  • acting as a growth factor by enhancing pH regulation through acid-base transport systems
  • having a direct antidiuretic action on the kidney, and also causing vasoconstriction of the peripheral vessels
  • adjusts the amount of AQP2 in the plasma membrane by triggering its redistribution from intracellular vesicles into the plasma membrane
  • enhances AQP2 protein abundance by altering its proteasomal degradation through a PRKA- and MAPK14-dependent pathway
  • affect liver glycogenolysis, insulin, and glucagon secretion and pituitary ACTH release
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recruited AQP2, but also AKAP7Vdelta to the plasma membrane
  • interacting with AQP2 (modulates the water channel aquaporin-2 (AQP2) in the renal collecting duct to maintain homeostasis of body water)
  • binds to AVPR2, increasing cAMP, which promotes the redistribution of AQP2 from intracellular vesicles into the plasma membrane
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DIR3
    related resource Neprhogenic diabetes Insipidus
    Susceptibility to diabetes mellitus
    Variant & Polymorphism other
  • elevated copeptin predicts increased risk for diabetes mellitus independently of established clinical risk factors, including fasting glucose and insulin
    • Candidate gene
    Marker
  • copeptin is a new promising prognostic marker for short-term mortality independently and additive to natriuretic peptide levels in patients with acute dyspnea
  • ischemia-modified albumin (IMA) and AVP detection is clinically useful in the early diagnosis and prognosis of acute carbon monoxide poisoning (ACOP)-related myocardial injury and in guiding early clinical drug application
  • AVP and ENO2 measured in the early postnatal period are potential prognostic biomarkers of long-term neurodevelopmental outcome in term neonates diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with therapeutic hypothermia
    • Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheroma 
    AVP system may be a therapeutic target in post-myocardial infarction left ventricular dysfunction
    ANIMAL & CELL MODELS