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FLASH GENE

Symbol

ALPP

contributors: npt/mct - updated : 28-01-2015

HGNC name	alkaline phosphatase, placental (Regan isozyme)
HGNC id	439

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	two glycosylation sites
	zinc-metalloprotein, made of a complex of identical subunits, each subunit containing one active site
	two zinc Zn2+ molecules, and magnesium Mg2+ as a cofactor
	a peripheral binding site may be involved in the functional specialization of the PLAP isozyme

secondary structure

N terminal alpha helix

conjugated

MetalloP

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to E.coli Plap

Homologene

FAMILY

alkaline phosphatase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION
	produced by the embryo and is found in maternal blood, where it is responsible for the rise of serum alkaline phosphatase during pregnancy
	involved in the intrauterine selection

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

reproduction/sex

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor,
	Mg2+
	Zn2+

protein

RBM3 has a role in enhancing the transcription of ALPP and BGLAP genes

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   ectopically expressed by cancer cells, in seminoma

Susceptibility

to abortion to deleterious action of maternal smoke on intrauterine survival and birthweight

Variant & Polymorphism other	isoform PLAPD increased in spontaneous abortion
	polymorphisms increasing deleterious action of maternal smoke on intrauterine survival and birthweight in women older than 28 years

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS