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FLASH GENE
Symbol ALPP contributors: npt/mct - updated : 28-01-2015
HGNC name alkaline phosphatase, placental (Regan isozyme)
HGNC id 439
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus    
Reproductivefemale systemplacenta   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • two glycosylation sites
  • zinc-metalloprotein, made of a complex of identical subunits, each subunit containing one active site
  • two zinc Zn2+ molecules, and magnesium Mg2+ as a cofactor
  • a peripheral binding site may be involved in the functional specialization of the PLAP isozyme
    • secondary structure N terminal alpha helix
    conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to E.coli Plap
    Homologene
    FAMILY
  • alkaline phosphatase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • produced by the embryo and is found in maternal blood, where it is responsible for the rise of serum alkaline phosphatase during pregnancy
  • involved in the intrauterine selection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mg2+
  • Zn2+
    • protein
  • RBM3 has a role in enhancing the transcription of ALPP and BGLAP genes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    ectopically expressed by cancer cells, in seminoma
    Susceptibility
  • to abortion
  • to deleterious action of maternal smoke on intrauterine survival and birthweight
    • Variant & Polymorphism other
  • isoform PLAPD increased in spontaneous abortion
  • polymorphisms increasing deleterious action of maternal smoke on intrauterine survival and birthweight in women older than 28 years
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS