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FLASH GENE
Symbol ALPP contributors: npt/mct - updated : 28-01-2015
HGNC name alkaline phosphatase, placental (Regan isozyme)
HGNC id 439
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2883 57 535 - Kam-Enthorn, Llinas (2005)
- - 2590 57 530 - Kam-Enthorn
- - 2700 57 513 - Kam-Millan
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus    
Reproductivefemale systemplacenta   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • two glycosylation sites
  • zinc-metalloprotein, made of a complex of identical subunits, each subunit containing one active site
  • two zinc Zn2+ molecules, and magnesium Mg2+ as a cofactor
  • a peripheral binding site may be involved in the functional specialization of the PLAP isozyme
    • secondary structure N terminal alpha helix
    conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to E.coli Plap
    Homologene
    FAMILY
  • alkaline phosphatase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • produced by the embryo and is found in maternal blood, where it is responsible for the rise of serum alkaline phosphatase during pregnancy
  • involved in the intrauterine selection
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mg2+
  • Zn2+
    • protein
  • RBM3 has a role in enhancing the transcription of ALPP and BGLAP genes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    ectopically expressed by cancer cells, in seminoma
    Susceptibility
  • to abortion
  • to deleterious action of maternal smoke on intrauterine survival and birthweight
    • Variant & Polymorphism other
  • isoform PLAPD increased in spontaneous abortion
  • polymorphisms increasing deleterious action of maternal smoke on intrauterine survival and birthweight in women older than 28 years
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS