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FLASH GENE
Symbol AHRR contributors: npt/ - updated : 10-04-2007
HGNC name aryl-hydrocarbon receptor repressor
HGNC id 346
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PAS domain
  • basic helix-loop-helix (bHLH) domain
  • a transcriptional repression domain within its C-terminal region, which exhibits a trichostatin A (TSA)-sensitive HDAC activity, interacting with ANKRA2
    • HOMOLOGY
    interspecies homolog to murine Ahr repressor
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • may mediate Ca(2+)- regulated signals along the death pathway
  • inhibit Aryl hydrocarbon receptor (AHR) activity by competing with AHR for forming a heterodimer with AHR nuclear translocator (ARNT)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ANKRA2 (ANKRA2 is important for transcriptional repression by AHRR)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in early stages of non-small cell lung cancer (Kang 2008)
    Susceptibility to micropenis(MP)
    Variant & Polymorphism other Pro185Ala polymorphism may constitute a susceptibility locus for the development of MP in response to dioxins
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS