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FLASH GENE
Symbol AHRR contributors: npt/ - updated : 10-04-2007
HGNC name aryl-hydrocarbon receptor repressor
HGNC id 346
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonamygdala  
 braindiencephalonhypothalamus  
 nerve   highly
Reproductivefemale systemuteruscervix highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PAS domain
  • basic helix-loop-helix (bHLH) domain
  • a transcriptional repression domain within its C-terminal region, which exhibits a trichostatin A (TSA)-sensitive HDAC activity, interacting with ANKRA2
    • HOMOLOGY
    interspecies homolog to murine Ahr repressor
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • may mediate Ca(2+)- regulated signals along the death pathway
  • inhibit Aryl hydrocarbon receptor (AHR) activity by competing with AHR for forming a heterodimer with AHR nuclear translocator (ARNT)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ANKRA2 (ANKRA2 is important for transcriptional repression by AHRR)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in early stages of non-small cell lung cancer (Kang 2008)
    Susceptibility to micropenis(MP)
    Variant & Polymorphism other Pro185Ala polymorphism may constitute a susceptibility locus for the development of MP in response to dioxins
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS