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FLASH GENE

Symbol

AHRR

contributors: npt/ - updated : 10-04-2007

HGNC name	aryl-hydrocarbon receptor repressor
HGNC id	346

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020731 12 - 5661 NP_065782 - 719 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon amygdala       brain diencephalon hypothalamus       nerve       highly Reproductive female system uterus cervix   highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	PAS domain
	basic helix-loop-helix (bHLH) domain
	a transcriptional repression domain within its C-terminal region, which exhibits a trichostatin A (TSA)-sensitive HDAC activity, interacting with ANKRA2

HOMOLOGY

interspecies

homolog to murine Ahr repressor

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,nucleus

basic FUNCTION	may mediate Ca(2+)- regulated signals along the death pathway
	inhibit Aryl hydrocarbon receptor (AHR) activity by competing with AHR for forming a heterodimer with AHR nuclear translocator (ARNT)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with ANKRA2 (ANKRA2 is important for transcriptional repression by AHRR)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification     in early stages of non-small cell lung cancer (Kang 2008)

Susceptibility

to micropenis(MP)

Variant & Polymorphism other	Pro185Ala polymorphism may constitute a susceptibility locus for the development of MP in response to dioxins

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS