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FLASH GENE
Symbol ADSL contributors: mct - updated : 07-04-2022
HGNC name adenylosuccinate lyase
HGNC id 291
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one lyase domain
  • HOMOLOGY
    interspecies murine Adsl
    Homologene
    FAMILY
  • lyase 1 family
  • adenylosuccinate lyase subfamily
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • twelfth step of the de novo purine (adenylate) biosynthesis, component of a bifunctional enzyme also catalyzing the eight step of the de novo purine biosynthesis, i.e, the conversion of SAICAR to AICAR (aminoimidazole carboxamide ribonucleotide)
  • involved in the purine nucleotide cycle
  • role of ADSL-mediated de novo purine synthesis in fueling mitochondrial ATP production to promote liver cancer cell growth
  • ADSL is an oncogene of Prostate carcinoma through regulating the cell cycle pathway firstly, with explicit cell and clinical phenotypes
  • ADSL functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • complex of purine biosynthesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ADSLD
    related resource Adenylosuccinate Lyase Mutations Database Home Page
    Susceptibility to autism
    Variant & Polymorphism other polymorphisms increasing the risk of autism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS