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FLASH GENE
Symbol ADSL contributors: mct - updated : 07-04-2022
HGNC name adenylosuccinate lyase
HGNC id 291
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1565 54 484 - 2000 10888601
12 - 1388 - 425 lowly expressed 2000 10888601
14 - 1799 - 480 - 2000 10888601
13 - 4304 - 420 - 2000 10888601
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
 salivary gland   highly
Endocrineneuroendocrinepituitary  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one lyase domain
  • HOMOLOGY
    interspecies murine Adsl
    Homologene
    FAMILY
  • lyase 1 family
  • adenylosuccinate lyase subfamily
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • twelfth step of the de novo purine (adenylate) biosynthesis, component of a bifunctional enzyme also catalyzing the eight step of the de novo purine biosynthesis, i.e, the conversion of SAICAR to AICAR (aminoimidazole carboxamide ribonucleotide)
  • involved in the purine nucleotide cycle
  • role of ADSL-mediated de novo purine synthesis in fueling mitochondrial ATP production to promote liver cancer cell growth
  • ADSL is an oncogene of Prostate carcinoma through regulating the cell cycle pathway firstly, with explicit cell and clinical phenotypes
  • ADSL functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • complex of purine biosynthesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ADSLD
    related resource Adenylosuccinate Lyase Mutations Database Home Page
    Susceptibility to autism
    Variant & Polymorphism other polymorphisms increasing the risk of autism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS