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FLASH GENE
Symbol ADRA2C contributors: mct - updated : 12-03-2008
HGNC name adrenergic, alpha-2C-, receptor
HGNC id 283
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Reproductivefemale systembreastmammary gland  
 female systemplacenta   
 female systemovary   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endosome
basic FUNCTION
  • required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons
  • involved in cold-induced constriction of cutaneous arteries
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by 17beta-estradiol by interacting with cell surface receptors (cause a cAMP/Rap2-dependent increase in ADRA2C transcription)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    may contribute to pathological changes in vascular function
    Susceptibility to congestive heart failure
    Variant & Polymorphism SNP increasing the risk of congestive heart failure
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS