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FLASH GENE
Symbol ACPP contributors: mct - updated : 24-01-2011
HGNC name acid phosphatase, prostate
HGNC id 125
Location 3q22.1      Physical location : 132.036.210 - 132.087.144
Synonym name prostatic acid phosphatase
Synonym symbol(s) ACP3, PAP, PACP, PSAP
EC.number 3.1.3.2
DNA
TYPE functioning gene
STRUCTURE 50.94 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
FLJ35880 3q22.1 hypothetical protein FLJ35880 LOC131873 3q22.1 hypothetical protein LOC131873 PIK3R4 3q22.1 phosphoinositide-3-kinase, regulatory subunit 4, p150 GSTO3P1 3q22.1 glutathione S-transferase omega 3 pseudogene 1 ATP2C1 3q21 ATPase, Ca++ transporting, type 2C, member 1 HT001 3q22.1 HT001 protein NEK11 3q21.3 NIMA (never in mitosis gene a)- related kinase 11 LOC152195 3q22.1 hypothetical protein LOC152195 LOC389149 3 LOC389149 FLJ31265 3q22.1 hypothetical protein FLJ31265 MRPL3 3q21.2-q23 mitochondrial ribosomal protein L3 CPNE4 3q22.1 copine IV LOC344568 3q22.1 similar to proteasome (prosome, macropain) 26S subunit, ATPase 2; Proteasome (prosome, macropain) 26S subunit, ATPase LOC391577 3 similar to ribosomal protein L7 ACPP 3q21.3-q23 acid phosphatase, prostate LOC131039 3q22.1 similar to Saccharomyces cerevisiae Nip7p homolog RME8 3q22.1 RME8 protein FLJ12592 3q22.1 putative acyl-CoA dehydrogenase CCRL1 3q22 chemokine (C-C motif) receptor-like 1 UBE1DC1 3q22 ubiquitin-activating enzyme E1-domain containing 1 NPHP3 3q22.1 nephronophthisis 3 (adolescent) MGC3040 3q21 hypothetical protein MGC3040 BFSP2 3q21.2q22.3 beaded filament structural protein 2, phakinin MGC2848 3q22.1 hypothetical protein MGC2848 LOC391578 3 similar to MAF1 homolog; MAF1 homolog (yeast) H41 3q22.1 hypothetical protein H41 TOPBP1 3q22.1 topoisomerase (DNA) II binding protein LOC391579 3 similar to RIKEN cDNA 1300017J02 TF 3q21 transferrin PRO2086 3q22.1 PRO2086 protein APMCF1 3q22.1 PRO2086 protein RAB6B 3q22.2 RAB6B, member RAS oncogene family FLJ22173 3q22.1 hypothetical protein FLJ22173 SLCO2A1 3q21 solute carrier organic anion transporter family, member 2A1 RYK 3q22 RYK receptor-like tyrosine kinase
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1842 - 418 widely expressed in nonprostatic tissues like brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid, and thymus 2010 20645695
  • TM-PAP
  • a type I transmembrane (TM) protein with the extracellular NH(2)-terminal phosphatase activity and the COOH-terminal lysosomal targeting signal (YxxPhi)
  • 10 - 3223 - 386 - 2010 20645695
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    Reproductiveepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • histidine acid phosphatase family
  • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • hydrolizing of orthophosphotic monoester to alcohol and orthophosphate
  • specifically, dephosphorylates extracellular adenosine monophosphate (AMP) to adenosine and activates A1-adenosine receptors in dorsal spinal cord
  • has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity
  • prostate tyrosine phosphatase involved in regulating prostate cell growth
  • authentic tyrosine phosphatase, that dephosphorylates ERBB2 and regulates prostate cancer cell growth
  • its major action is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by upregulated by androgen
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target novel use for PAP in the treatment of chronic pain
    SystemTypeDisorderPubmed
    neurologyacquired 
    cancerreproductiveprostate
    ANIMAL & CELL MODELS