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FLASH GENE
Symbol ACPP contributors: mct - updated : 24-01-2011
HGNC name acid phosphatase, prostate
HGNC id 125
Location 3q22.1      Physical location : 132.036.210 - 132.087.144
Synonym name prostatic acid phosphatase
Synonym symbol(s) ACP3, PAP, PACP, PSAP
EC.number 3.1.3.2
DNA
TYPE functioning gene
STRUCTURE 50.94 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1842 - 418 widely expressed in nonprostatic tissues like brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid, and thymus 2010 20645695
  • TM-PAP
  • a type I transmembrane (TM) protein with the extracellular NH(2)-terminal phosphatase activity and the COOH-terminal lysosomal targeting signal (YxxPhi)
  • 10 - 3223 - 386 - 2010 20645695
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    Reproductiveepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • histidine acid phosphatase family
  • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • hydrolizing of orthophosphotic monoester to alcohol and orthophosphate
  • specifically, dephosphorylates extracellular adenosine monophosphate (AMP) to adenosine and activates A1-adenosine receptors in dorsal spinal cord
  • has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity
  • prostate tyrosine phosphatase involved in regulating prostate cell growth
  • authentic tyrosine phosphatase, that dephosphorylates ERBB2 and regulates prostate cancer cell growth
  • its major action is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by upregulated by androgen
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target novel use for PAP in the treatment of chronic pain
    SystemTypeDisorderPubmed
    neurologyacquired 
    cancerreproductiveprostate
    ANIMAL & CELL MODELS