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FLASH GENE
Symbol ADA contributors: - updated : 13-10-2006
HGNC name adenosine deaminase
HGNC id 186
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a deaminase motif
HOMOLOGY
interspecies ortholog to rattus Ada
ortholog to murine Ada
Homologene
FAMILY
  • metallopeptidase family
  • adenosine and amidohydrolase superfamily
    • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the hydrolysis of adenosine to inosine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • antimicrobial humoral response
    • PATHWAY
    metabolism purine/pyrimidine
    signaling
  • nucleotide metabolism, purine ribonucleoside monophosphate biosynthesis
    • a component component of the mammalian STAGA (SUPT3H-TAF9-ADA-PCAF acetyltransferase) a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ADA
    related resource Mutation registry for Adenosine Deaminase Deficiency -ADAbase
    Susceptibility ADA variant not involved in susceptibility to essential hypertension
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS