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FLASH GENE
Symbol ADA contributors: - updated : 13-10-2006
HGNC name adenosine deaminase
HGNC id 186
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestiveintestinesmall intestine  moderately
Lymphoid/Immunelymph node   highly
 thymus   predominantly
Reproductivefemale systemuteruscervix highly
 male systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
Text during weaning, in gastrointestinal tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a deaminase motif
HOMOLOGY
interspecies ortholog to rattus Ada
ortholog to murine Ada
Homologene
FAMILY
  • metallopeptidase family
  • adenosine and amidohydrolase superfamily
    • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the hydrolysis of adenosine to inosine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • antimicrobial humoral response
    • PATHWAY
    metabolism purine/pyrimidine
    signaling
  • nucleotide metabolism, purine ribonucleoside monophosphate biosynthesis
    • a component component of the mammalian STAGA (SUPT3H-TAF9-ADA-PCAF acetyltransferase) a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ADA
    related resource Mutation registry for Adenosine Deaminase Deficiency -ADAbase
    Susceptibility ADA variant not involved in susceptibility to essential hypertension
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS