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FLASH GENE

Symbol

ADA

contributors: - updated : 13-10-2006

HGNC name	adenosine deaminase
HGNC id	186

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	32.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

including a locus control region LCR-ADA (see symbol) in intron 1

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - SRC - D20S44 - D20S46 - D20S55 - D20S43 - D20S150 - D20S169 - D20S89 - ADA ADA /D20S119 - D20S424 - D20S481 - PPGB - MMP9 - D20S17 - D20S16 - D20S75 - D20S33 - qter
Authors	Rotschild (93), Ting (93), Stöffel (96)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ADA1 - - 1566 - 363 - Luo ADA2 - - - - - - Zavialov heparin-binding protein member of a new class of ADGFs (ADA-related growth factors) may be active in sites of inflammation during hypoxia and in areas of tumour growth where the adenosine concentration is significantly elevated and the extracellular pH is acidic

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       moderately Digestive intestine small intestine     moderately Lymphoid/Immune lymph node       highly   thymus       predominantly Reproductive female system uterus cervix   highly   male system testis     highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

Text	during weaning, in gastrointestinal tissue

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a deaminase motif

HOMOLOGY

interspecies	ortholog to rattus Ada
	ortholog to murine Ada

Homologene

FAMILY	metallopeptidase family
	adenosine and amidohydrolase superfamily

CATEGORY

enzyme , immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

catalyzing the hydrolysis of adenosine to inosine

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	antimicrobial humoral response

PATHWAY

metabolism

purine/pyrimidine

signaling

nucleotide metabolism, purine ribonucleoside monophosphate biosynthesis

a component

component of the mammalian STAGA (SUPT3H-TAF9-ADA-PCAF acetyltransferase) a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ADA

related resource

Mutation registry for Adenosine Deaminase Deficiency -ADAbase

Susceptibility

ADA variant not involved in susceptibility to essential hypertension

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS