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FLASH GENE
Symbol CHRNA4 contributors: mct - updated : 18-09-2012
HGNC name cholinergic receptor, nicotinic, alpha polypeptide 4
HGNC id 1958
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N terminal extracellular domain
  • two agonist binding sites
  • four transmembrane segments (4TM)
  • the M2 domain comprising the cation-selective pore
    • conjugated GlycoP
    mono polymer heteromer , pentamer
    HOMOLOGY
    Homologene
    FAMILY cholinergic receptor family
    CATEGORY receptor membrane ligand ion channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cholinergic receptor, nicotinic, ligand gated ion channel, mediating fast signal transmission at synapses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component heteropentamer alpha 4(2), beta 2 (3subunits)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ENFL1
    Susceptibility
  • to nicotine addiction
  • to attentional network deficits
  • to sporadic amyotrophic lateral sclerosis
    • Variant & Polymorphism SNP , other
  • variations in CHRNA4 exon 5 associated with attentional network deficits
  • missense variants are associated with sporadic amyotrophic lateral sclerosis
  • rs1044396 affects attention and negative emotionality in normal adults
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS