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FLASH GENE

Symbol

CD48

contributors: mct/pgu - updated : 16-07-2010

HGNC name	CD48 molecule
HGNC id	1683

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001778 4 - 1099 NP_001769 - 243 - 1999 10359122

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   thymus       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic plasma       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune natural killer

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Ig-like C2-type (immunoglobulin-like) domain
	a Ig-like V-type (immunoglobulin-like) domain

conjugated

GlycoP , LipoP

HOMOLOGY

Homologene

FAMILY	immunoglobulin superfamily
	SLAM family

CATEGORY

immunity/defense , antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	attached to the membrane by a GPI-anchor

basic FUNCTION	may be involved in regulating T-cell activation
	ligand for CD2
	might facilitate interaction between activated lymphocytes
	cooperating with CD2 in the buildup of the early TCR signalosome and shuttling the transmembrane adapter membrane LAT
	induces numerous effects in B and T lymphocytes, natural killer cells, mast cells, and eosinophils
	SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
	plays a vital role as an environmental sensor for regulating hematopoietic cells and progenitor cell numbers and inhibiting tumor development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to 2B4
	binds CD2 and other molecules

cell & other

REGULATION

Other

its expression is regulated by viral and bacterial products and immune-associated proteins

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

may have a role in the susceptibility to EBV infection in patients with mutation in XPLD disease gene

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS