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FLASH GENE
Symbol IL12A contributors: mct - updated : 14-04-2017
HGNC name interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
HGNC id 5969
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine    
Lymphoid/Immunespleen    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine IL12A
Homologene
FAMILY
  • interleukin family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • natural killer cell stimulatory factor 1
  • cytotoxic lymphocyte maturation factor 1
  • stimulating IFNG production
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense
    text growth factor for activated T and NK cells; IL12 is a signal of the innate immune system
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with IL12B
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enhancement of SIRT1 activity in response to phagocytic stimuli may reduce the accessibility of REL to the IL12A promoter and its transcriptional activation, thus regulating the IL12 p70/IL12B balance and modulating the ongoing immune response
  • DDR2 is involved in the collagen I-induced IL12A production via NFKB1 and JNK pathway
  • MAP2K1 is required for TLR4 mediated ERK activation and in turn regulates the production of IL10 and IL12A
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric carcinoma with poor prognosis
    Susceptibility
  • to systemic lupus erythematosus patients (SLE)
  • to primary biliary cirrhosis (PBC)
    • Variant & Polymorphism SNP SNPs within SCHIP1 (located ~100 kb proximal to IL12A) showed suggestive association with PBC
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmuneLupus
    may be therapeutic targets in SLE
    ANIMAL & CELL MODELS