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FLASH GENE

Symbol

IL12A

contributors: mct - updated : 14-04-2017

HGNC name	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
HGNC id	5969

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	7.18 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000882 7 - 1444 NP_000873 - 253 - 2007 17461482

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Lymphoid/Immune spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine IL12A

Homologene

FAMILY

interleukin family

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	natural killer cell stimulatory factor 1
	cytotoxic lymphocyte maturation factor 1
	stimulating IFNG production

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

immunity/defense

text	growth factor for activated T and NK cells; IL12 is a signal of the innate immune system

PATHWAY

metabolism

signaling

a component

dimerizing with IL12B

INTERACTION

DNA

RNA

small molecule

protein	enhancement of SIRT1 activity in response to phagocytic stimuli may reduce the accessibility of REL to the IL12A promoter and its transcriptional activation, thus regulating the IL12 p70/IL12B balance and modulating the ongoing immune response
	DDR2 is involved in the collagen I-induced IL12A production via NFKB1 and JNK pathway
	MAP2K1 is required for TLR4 mediated ERK activation and in turn regulates the production of IL10 and IL12A

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric carcinoma with poor prognosis

Susceptibility

to systemic lupus erythematosus patients (SLE) to primary biliary cirrhosis (PBC)

Variant & Polymorphism SNP	SNPs within SCHIP1 (located ~100 kb proximal to IL12A) showed suggestive association with PBC

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune Lupus may be therapeutic targets in SLE

ANIMAL & CELL MODELS