Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TFF2 contributors: mct - updated : 02-02-2015
HGNC name trefoil factor 2
HGNC id 11756
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three intrachain disulfide bonds (TFF domains), forming the three leaf structure (two P-type trefoil motif)
  • N terminus consensus site for N glycosylation
    • conjugated GlycoP
    isoforms Precursor a 23 aa signal peptide (2.3 kda), a 106 aa mature peptide (12 kda)
    HOMOLOGY
    interspecies homolog to rattus Tff2 (79.1pc)
    homolog to murine Tff2 (81.4pc)
    Homologene
    FAMILY
  • trefoil family
    • CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be functioning as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains
  • protective against mucosal damaging agents
  • inhibiting gastrointestinal motility and gastric acid secretion
  • could play a role in mammary gland tumorigenesis
  • may enhance mucosal healing by modulating motogenic activity, inhibiting apoptosis, and promoting angiogenesis
  • promote regeneration and repair processes of mucous epithelia
  • participates in mucus stabilization and repair, apoptosis, and inflammatory responses
  • is potentially a mastermind in the control of energy balance and a promising therapeutic target for obesity 3)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion , immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CXCR4 is a bona fide signaling receptor for TFF2, suggesting a mechanism through which TFF2 may modulate immune and tumorigenic responses
  • promotes cell migration via F2RL3
    • cell & other
    REGULATION
    Other regulation of TFF2 by gastrin may play a role in the maintenance and repair of the gastrointestinal mucosa
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in gastritis ulceration and metaplasia
    tumoral     --over  
    in some digestive tumors (stomach, pancreas, biliary tract)
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • TFF2 and probably also TFF3 are candidate biomarkers for nephrolithiasis and possibly other inflammatory conditions of the urinary tract
    • Therapy target
    ANIMAL & CELL MODELS