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FLASH GENE
Symbol TFF2 contributors: mct - updated : 02-02-2015
HGNC name trefoil factor 2
HGNC id 11756
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   specific
Respiratoryrespiratory tractlarynx  moderately
Visualeyeretina    Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three intrachain disulfide bonds (TFF domains), forming the three leaf structure (two P-type trefoil motif)
  • N terminus consensus site for N glycosylation
    • conjugated GlycoP
    isoforms Precursor a 23 aa signal peptide (2.3 kda), a 106 aa mature peptide (12 kda)
    HOMOLOGY
    interspecies homolog to rattus Tff2 (79.1pc)
    homolog to murine Tff2 (81.4pc)
    Homologene
    FAMILY
  • trefoil family
    • CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be functioning as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains
  • protective against mucosal damaging agents
  • inhibiting gastrointestinal motility and gastric acid secretion
  • could play a role in mammary gland tumorigenesis
  • may enhance mucosal healing by modulating motogenic activity, inhibiting apoptosis, and promoting angiogenesis
  • promote regeneration and repair processes of mucous epithelia
  • participates in mucus stabilization and repair, apoptosis, and inflammatory responses
  • is potentially a mastermind in the control of energy balance and a promising therapeutic target for obesity 3)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion , immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CXCR4 is a bona fide signaling receptor for TFF2, suggesting a mechanism through which TFF2 may modulate immune and tumorigenic responses
  • promotes cell migration via F2RL3
    • cell & other
    REGULATION
    Other regulation of TFF2 by gastrin may play a role in the maintenance and repair of the gastrointestinal mucosa
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in gastritis ulceration and metaplasia
    tumoral     --over  
    in some digestive tumors (stomach, pancreas, biliary tract)
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • TFF2 and probably also TFF3 are candidate biomarkers for nephrolithiasis and possibly other inflammatory conditions of the urinary tract
    • Therapy target
    ANIMAL & CELL MODELS