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FLASH GENE

Symbol

ZNF74

contributors: - updated : 19-05-2006

HGNC name	zinc finger protein 74 (Cos52)
HGNC id	13144

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a truncated KRAB Krüppel associated box at the N terminus and twelve zinc finger motifs of the C2H2 Kruppel type at the C terminus

conjugated

MetalloP

HOMOLOGY

interspecies	homolog to Drosophila CG9797
	homolog to C.elegans Y56A3A.16

Homologene

FAMILY

zinc finger protein family,C2H2 type,KRAB subfamily

CATEGORY

RNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus
text	nuclear matrix

basic FUNCTION	potential transcriptional repressor
	playing a role in RNA metabolism

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

nucleic

signaling

RNA metabolism

a component

INTERACTION

DNA

binding

RNA	binding to poly(U) and poly(G) RNAs

small molecule	metal binding,
	zinc Zn2+

protein

cell & other

binding to the nuclear matrix

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS