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FLASH GENE
Symbol ZNF74 contributors: - updated : 19-05-2006
HGNC name zinc finger protein 74 (Cos52)
HGNC id 13144
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vessels    
 vesselsaorta   
digestiveesophagus    
Nervousspinal cord    
reproductiverespiratory tract    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialbarrier/liningendothelium  
Epithelialbarrier/lining   
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a truncated KRAB Krüppel associated box at the N terminus and twelve zinc finger motifs of the C2H2 Kruppel type at the C terminus
conjugated MetalloP
HOMOLOGY
interspecies homolog to Drosophila CG9797
homolog to C.elegans Y56A3A.16
Homologene
FAMILY zinc finger protein family,C2H2 type,KRAB subfamily
CATEGORY RNA associated , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
text nuclear matrix
basic FUNCTION
  • potential transcriptional repressor
  • playing a role in RNA metabolism
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism nucleic
    signaling
    RNA metabolism
    a component
    INTERACTION
    DNA binding
    RNA binding to poly(U) and poly(G) RNAs
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other binding to the nuclear matrix
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS