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FLASH GENE

Symbol

COX6B1

contributors: mct/npt - updated : 02-07-2008

HGNC name	cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous)
HGNC id	2280

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES		instable
STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Cox6b1

Homologene

FAMILY

cytochrome c oxidase VIb family

CATEGORY

enzyme , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,interspace

basic FUNCTION	cytochrome c oxidase activity
	may be involved in the regulation and assembly of the complex
	connecting the two COX monomers into the physiological dimeric form

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

text	4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O

PATHWAY

metabolism

energetic

signaling

a component

component of the cytochrome oxidase c complex (the terminal enzyme in the mitochondrial respiratory chain transferring electron from reduced cytochrome c to oxygen)

INTERACTION

DNA

RNA

small molecule
	may be one of the heme binding subunits

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

COX6B1D

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS