Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

EGR4

contributors: mct - updated : 24-10-2014

HGNC name	early growth response 4
HGNC id	3241

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three C2H2-type zinc fingers

HOMOLOGY

interspecies	homolog to rattus Egr4 (86.8 pc)
	homolog to murine Egr4 (86.4 pc)

Homologene

FAMILY

EGR C2H2-type zinc-finger protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

activating the transcription of target genes whose products are required for mitogenesis and differentiation

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

text	positive regulation of cell proliferation

PATHWAY

metabolism

signaling

calcineurin signaling pathway

a component

INTERACTION

DNA	binding to the sequence 5'-GCGGGGGCG-3'

RNA

small molecule	metal binding,
	Zn2+

protein

EGR4 is an important component in the mechanism of BDNF-dependent SLC12A5 gene regulation via the ERK1/2 pathway in immature neurons

cell & other

REGULATION

induced by	serum
		PHA/PMA

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS