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FLASH GENE
Symbol EGR4 contributors: mct - updated : 24-10-2014
HGNC name early growth response 4
HGNC id 3241
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung   specific
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three C2H2-type zinc fingers
    • HOMOLOGY
    interspecies homolog to rattus Egr4 (86.8 pc)
    homolog to murine Egr4 (86.4 pc)
    Homologene
    FAMILY
  • EGR C2H2-type zinc-finger protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activating the transcription of target genes whose products are required for mitogenesis and differentiation
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text positive regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    calcineurin signaling pathway
    a component
    INTERACTION
    DNA binding to the sequence 5'-GCGGGGGCG-3'
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • EGR4 is an important component in the mechanism of BDNF-dependent SLC12A5 gene regulation via the ERK1/2 pathway in immature neurons
    • cell & other
    REGULATION
    induced by serum
    PHA/PMA
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS