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FLASH GENE
Symbol EGR4 contributors: mct - updated : 24-10-2014
HGNC name early growth response 4
HGNC id 3241
Location 2p13      Physical location : 73.518.057 - 73.520.829
Synonym name
  • immediate early growth response, gene 4 (pAT133), nerve growth factor induced clone C
    • Synonym symbol(s) NGF1C, NGFIC, NGFI-C, PAT133, AT133
    DNA
    TYPE functioning gene
    STRUCTURE 2.00 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located in the PARK3 region
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung   specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three C2H2-type zinc fingers
    • HOMOLOGY
    interspecies homolog to rattus Egr4 (86.8 pc)
    homolog to murine Egr4 (86.4 pc)
    Homologene
    FAMILY
  • EGR C2H2-type zinc-finger protein family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activating the transcription of target genes whose products are required for mitogenesis and differentiation
    • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text positive regulation of cell proliferation
    PATHWAY
    metabolism
    signaling
    calcineurin signaling pathway
    a component
    INTERACTION
    DNA binding to the sequence 5'-GCGGGGGCG-3'
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • EGR4 is an important component in the mechanism of BDNF-dependent SLC12A5 gene regulation via the ERK1/2 pathway in immature neurons
    • cell & other
    REGULATION
    induced by serum
    PHA/PMA
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS