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FLASH GENE

Symbol

HOXD13

contributors: mct/pgu - updated : 29-03-2017

HGNC name	homeobox D13
HGNC id	5136

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PSDY2 , BDD , SDTY5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in a VACTERL patient tumoral     --over   higher in progesterone receptor-positive cancer tissues than negative cancer tissues

Susceptibility

Variant & Polymorphism repeat	triplet polyalamine expansion

Candidate gene	HOXD13 methylation could therefore potentially be used as a prognostic factor for breast cancer
Marker
Therapy target

ANIMAL & CELL MODELS

loss of Hoxa13 and Hoxd13 transcription factors (Hox13) leads to digit agenesis in mice