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FLASH GENE

Symbol

HOXD12

contributors: mct/npt - updated : 18-12-2009

HGNC name	homeobox D12
HGNC id	5135

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PSDY2 polysyndactyly 2
Location	2q31.1      Physical location : 176.964.529 - 176.965.488
Synonym name	homeo box D12 (4H)
	Hox-4.7, mouse, homolog of
Synonym symbol(s)	HOX4H, HXDC

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
STRUCTURE	0.96 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HOXD@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021193 3 - 813 NP_067016 - 270 - Shen (1997)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies

homolog to murine Hox-4.7

Homologene

FAMILY

ABD-B homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

unknown

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to HOD13 during mouse limb development

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PSDY2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   higher in progesterone receptor-positive cancer tissues than negative cancer tissues (Makiyama 2005)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS