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FLASH GENE

Symbol

GRIA2

contributors: mct/shn - updated : 08-11-2015

HGNC name	glutamate receptor, ionotropic, AMPA 2
HGNC id	4572

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NEDLIB

Susceptibility

to amyotrophic lateral sclerosis

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Crossbreeding of the hSOD1G93A transgenic mouse model of ALS with chat-GluR2 mice led to marked delay of disease onset and mortality (
	expression of the GRIA2 subunit was significantly reduced in the ventral hippocampus and the postrhinal cortex of aged rat (
	GluR2 heterozygous knock-in mouse display severe and progressive neurological deficits including seizures and, ultimately, increased mortality (