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Symbol GRIA2 contributors: mct/shn - updated : 08-11-2015
HGNC name glutamate receptor, ionotropic, AMPA 2
HGNC id 4572
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ligand binding site in the N terminal region
  • four transmembrane segments (4TM),one of which forming the wall of the channel
  • a large intracellular loop
    • isoforms Precursor with flip and flop isoforms
    HOMOLOGY
    interspecies ortholog to Gria2, Mus musculus
    ortholog to Gria2, Rattus norvegicus
    ortholog to GRIA2, Pan troglodytes
    Homologene
    FAMILY
  • glutamate-gated ion channel family
  • GRIA2 subfamily
    • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • expressed on neuronal the plasma membranes on the external surfaces of soma, dendrites, and spines (
  • expressed in recycling endosomes (
    • basic FUNCTION
  • glutamate receptor,subunit 2,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class, mediating the fast component of excitatory post synaptic currents in the central nervous system
  • the plasma membrane delivery of GRIA2 containing AMPA receptors is regulated by its unique structural elements (
  • with GRIA1, GRIA3, GRIN2B, mediate fast synaptic transmission in the brain
  • regulates metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) and is indispensable for mGluR-LTD in the hippocampus (
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-binding protein (ABP) (
  • protein interacting with C kinase, PICK1 (
  • GluR1, 3 and 4 (
  • syntenin (
  • N-ethylmaleimide-sensitive factor, NSF (
  • interacting with and signaling through the protein-kinase LYN, PRKCABP
  • on GRIA2, B3GAT1 regulates cell surface stability of GRIA2 by modulating the interaction with CDH2
  • GRIP1 and GRIP2 (bind to the C-termini of AMPA-R GRIA2 and GRIA3 subunits)
  • GRIA2-PICK1 interactions are a key component of the effects of APP on synapses
  • activity-dependent trafficking of GRIP1 to synaptic sites drives the forward trafficking and enhanced synaptic accumulation of GRIA2-containing AMPAR during synaptic scaling up
  • CPT1C binds GRIA1 and GRIA2 and that the three proteins have the same expression profile during neuronal maturation
  • dual roles for PACSIN1 in controlling the internalization and recycling of GRIA2 after NMDAR activation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEDLIB
    Susceptibility to amyotrophic lateral sclerosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Crossbreeding of the hSOD1G93A transgenic mouse model of ALS with chat-GluR2 mice led to marked delay of disease onset and mortality (
  • expression of the GRIA2 subunit was significantly reduced in the ventral hippocampus and the postrhinal cortex of aged rat (
  • GluR2 heterozygous knock-in mouse display severe and progressive neurological deficits including seizures and, ultimately, increased mortality (