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FLASH GENE
Symbol PFKFB2 contributors: mct - updated : 08-06-2021
HGNC name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
HGNC id 8873
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon moderately
 pancreas exocrine   moderately
Endocrinethyroid   predominantly
Lymphoid/Immunespleen   moderately
 thymus   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
 male systemtestis  moderately
Respiratoryrespiratory tractlarynx  highly
 respiratory tracttrachea  moderately
Skin/Tegumentskin   highly
Urinarybladder   moderately
 kidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ATP binding site
  • two fructose-6-phosphate binding site
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Pfkfb2
    ortholog to murine Pfkfb2
    Homologene
    FAMILY
  • phosphoglycerate mutase family, in the C-terminal section
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acting as a 6-phosphofructo-2-kinase
  • acting as a fructose 2,6-biphosphatase 2
  • involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis
  • regulates glycolysis and proliferation in pancreatic cancer cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • synthesis and degradation of fructose 2,6-bisphosphate
    • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • ATP
  • fructose-6-phosphate
    • protein
  • MACC1 may affect hepatocellular carcinoma metabolism partly through expression and phophorylation of PFKFB2
    • cell & other
    REGULATION
    activated by phosphorylation, for the kinase activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly higher in hepatocellular carcinoma than in the corresponding nontumor tissues
    constitutional     --over  
    in placentas from pregnancies with IUGR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
  • PFKFB2 promoter methylation analysis has potential applicability to better stratify WDTC patients according to the recurrence risk
    • Therapy target
    ANIMAL & CELL MODELS