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FLASH GENE

Symbol

PFKFB2

contributors: mct - updated : 08-06-2021

HGNC name	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
HGNC id	8873

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	27.96 kb     16 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006212 15 splicing 7073 NP_006203 58 505 - 2019 30819197 containing exons 1 to 15 NM_001018053 15 splicing 3533 NP_001018063 54 471 heart 2019 30819197 containing exons 1 to 14 and 16 differing in the 3' UTR and coding region compared to variant 1

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon   moderately   pancreas exocrine       moderately Endocrine thyroid       predominantly Lymphoid/Immune spleen       moderately   thymus       highly Nervous brain       moderately Reproductive male system prostate     moderately   male system testis     moderately Respiratory respiratory tract larynx     highly   respiratory tract trachea     moderately Skin/Tegument skin       highly Urinary bladder       moderately   kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an ATP binding site
	two fructose-6-phosphate binding site

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to rattus Pfkfb2
	ortholog to murine Pfkfb2

Homologene

FAMILY

phosphoglycerate mutase family, in the C-terminal section

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	acting as a 6-phosphofructo-2-kinase
	acting as a fructose 2,6-biphosphatase 2
	involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis
	regulates glycolysis and proliferation in pancreatic cancer cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

synthesis and degradation of fructose 2,6-bisphosphate

a component

INTERACTION

DNA

RNA

small molecule	nucleotide, other,
	ATP
	fructose-6-phosphate

protein

MACC1 may affect hepatocellular carcinoma metabolism partly through expression and phophorylation of PFKFB2

cell & other

REGULATION

activated by

phosphorylation, for the kinase activity

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly higher in hepatocellular carcinoma than in the corresponding nontumor tissues constitutional     --over   in placentas from pregnancies with IUGR

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	biomarker for thyroid cancer exhibiting differences in the correlation coefficients between benign and malignant samples that indicate its discriminatory power
	PFKFB2 promoter methylation analysis has potential applicability to better stratify WDTC patients according to the recurrence risk
Therapy target

ANIMAL & CELL MODELS