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FLASH GENE
Symbol ITGAV contributors: mct - updated : 24-10-2006
HGNC name integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
HGNC id 6150
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal large extracellular domain with a sevenfold repeated structure
  • putative cation-binding motifs in the three of four C terminal repeats, proteolytically processed into disulfide linked heavy and light chains
  • an extracellular domain connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin family
    CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS cardiovascular , development
    text vasculogenesis angiogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with ITGB3 in vitronectin,fibrinogen,von Willebrand factor, thrombospondin, fibronectin, osteopontin, collagen receptors, with ITGB1 or ITGB5 in vitronectin receptor, with ITGB6 in fibronectin receptor
    • INTERACTION
    DNA
    RNA
    small molecule
    protein binding FGF1, and playing a role in FGF1 signaling
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS