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FLASH GENE
Symbol ITGAV contributors: mct - updated : 24-10-2006
HGNC name integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
HGNC id 6150
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Endocrineparathyroid   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal large extracellular domain with a sevenfold repeated structure
  • putative cation-binding motifs in the three of four C terminal repeats, proteolytically processed into disulfide linked heavy and light chains
  • an extracellular domain connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin family
    CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS cardiovascular , development
    text vasculogenesis angiogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with ITGB3 in vitronectin,fibrinogen,von Willebrand factor, thrombospondin, fibronectin, osteopontin, collagen receptors, with ITGB1 or ITGB5 in vitronectin receptor, with ITGB6 in fibronectin receptor
    • INTERACTION
    DNA
    RNA
    small molecule
    protein binding FGF1, and playing a role in FGF1 signaling
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS