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FLASH GENE

Symbol

ITGAV

contributors: mct - updated : 24-10-2006

HGNC name	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
HGNC id	6150

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Endocrine parathyroid       highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal large extracellular domain with a sevenfold repeated structure
	putative cation-binding motifs in the three of four C terminal repeats, proteolytically processed into disulfide linked heavy and light chains
	an extracellular domain connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

integrin family

CATEGORY

adhesion , antigen , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

cardiovascular , development

text	vasculogenesis angiogenesis

PATHWAY

metabolism

signaling

a component

dimerizing with ITGB3 in vitronectin,fibrinogen,von Willebrand factor, thrombospondin, fibronectin, osteopontin, collagen receptors, with ITGB1 or ITGB5 in vitronectin receptor, with ITGB6 in fibronectin receptor

INTERACTION

DNA

RNA

small molecule

protein

binding FGF1, and playing a role in FGF1 signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS