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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TACR1

contributors: mct - updated : 22-10-2013

HGNC name	tachykinin receptor 1
HGNC id	11526

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in the pancreatic cancer cell lines

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast treatment of TACR1 antagonist exerted antitumor action in breast cancer cells with NK1R-Tr high expression cancer digestive pancreas blocking the TAC1/TACR1 signaling system is a novel strategy for the treatment of pancreatic cancer miscelleaneous vascular   antagonists (NK1-RA) may have a role in developing novel therapeutic approaches to patients vulnerable to vaso-occlusive disorders

ANIMAL & CELL MODELS

bone marrow taken from Nk1r deficient mice (Tacr1(-/-) showed lineage specific B and T cell engraftment deficits compared to wild-type competitor bone marrow cells