| basic FUNCTION
| produced by activated monocytes and neutrophils and expressed at sites of inflammation |
|
critical C-X-C chemokine secreted by macrophages and epithelial cells, and a potent chemoattractant for neutrophils  |
|
CXCL1 and CXCL2 play important roles in the infiltration of neutrophils into the site of injection of necrotic cells |
|
is a mediator in the development of sepsis |
|
regulate immune functions mainly by chemo-attracting neutrophils |
|
during osteoclastogenesis CXCL2 stimulated the adhesion and the migration of bone marrow-derived macrophages (BMMs) |
|
plays a role in bone destruction associated with oral squamous cell carcinoma |
|
roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue |
|
mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation |
|
novel role of CXCL1 and CXCL2 in promoting mo-MDSC (monocytic myeloid-derived suppressor cells) generation by favoring the differentiation of bone marrow cells in tumor-bearing conditions, which suggests that inhibition of CXCL1 and CXCL2 could decrease mo-MDSC generation and improve host immunosurveillance |
|
critical for correct breaching of endothelial junctions |
|
CXCL1 and CXCL2 act in a sequential manner to guide neutrophils through venular walls as governed by their distinct cellular sources |
