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FLASH GENE
Symbol DRD5 contributors: mct - updated : 16-09-2015
HGNC name dopamine receptor D5
HGNC id 3026
Corresponding disease
DTPC primary cervical dystonia
Location 4p16.1      Physical location : 9.783.257 - 9.785.632
Synonym name
  • D(5) dopamine receptor
  • D1beta dopamine receptor
  • Synonym symbol(s) DBDR, DRD1B, DRD1L2, MGC10601, D5R
    DNA
    TYPE functioning gene
    STRUCTURE 2.38 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    LOC391624 4 similar to ubiquitin-specific protease 17-like protein LOC391625 4 similar to ubiquitin-specific protease 17-like protein LOC391626 4 similar to ubiquitin-specific protease 17-like protein LOC391627 4 similar to ubiquitin-specific protease 17-like protein LOC391628 4 similar to ubiquitin-specific protease 17-like protein LOC389200 4 similar to hypothetical protein LOC169270 LOC285479 4p16.1 hypothetical gene supported by NM_030930; AY007125 LOC391629 4 similar to seven transmembrane helix receptor LOC391630 4 similar to seven transmembrane helix receptor LOC391631 4 similar to Alkaline sphingomyelinase LOC285544 4p16.1 similar to mannosyltransferase LOC391632 4 similar to putative taste receptor HTR2 LOC389201 4 LOC389201 DRD5 4p16.1 dopamine receptor D5 SLC2A9 4p16-p15.3 solute carrier family 2 (facilitated glucose transporter), member 9 WDR1 4p16.1 WD repeat domain 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2398 - 477 - 1992 1387108
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampusdentate gyruspredominantly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • dopamine receptor D5, high affinity, adenylate cyclase stimulating
  • mediates AGTR1 degradation via a ubiquitin-proteasome pathway
  • its activation ubiquitination of the glycosylated AT1R at the plasma membrane
  • dentate gyrus DRD1, but not DRD5, contribute to the formation of distinct contextual representations of novel environments
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • complexing with GABA-A receptor complex through binding to DRD5 and promoting mutually inhibitory functional interactions between these receptor systems
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • crucial role for SNX1 in DRD5 trafficking and SNX1 depletion results in DRD5 dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DTPC
    Susceptibility
  • to blepharospasm (OMIM 606798)
  • to attention deficit hyperactivity disorder (Adhd) with preferential transmission of paternal alleles
  • to schizophrenia, not bipolar disorder
  • Variant & Polymorphism repeat , other
  • allele 2 of dinucleotide repeat significantly associated with blepharospasm
  • variant in DRD5 may affect age at onset for ADHD
  • Candidate gene for primary cervical dystonia (allele 4 of (CT/GT/GA)n microsatellite is associated with cervical dystonia)
    Marker
    Therapy target
  • therapy for hypertension might be optimized by designing compounds that can target the AGTR1 and DRD5
  • ANIMAL & CELL MODELS