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FLASH GENE
Symbol MAP2 contributors: shn/npt - updated : 12-10-2009
HGNC name microtubule-associated protein 2
HGNC id 6839
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three or four copies of a 18 AA repeat
  • the microtubule-binding domain in the C terminal region
  • four TAU/MAP repeats
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to Map2, Rattus norvegicus
    ortholog to Mtap2, Mus musculus
    ortholog to MAP2, Pan troglodytes
    Homologene
    FAMILY
  • MAP (mitogen activated protein) kinase family
  • microtubule-associated protein family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text axons, dendrites, cell bodies
    basic FUNCTION
  • maintenance of neuronal morphology by regulating the spacing of microtubules
  • involved in microtubule assembly a crucial step in neurogenesis
  • linking microtubules to other elements of the cytoskeleton
  • playing a role in microtubule stabilization
  • playing a role primarily in neurite outgrowth during neuronal development
  • may function in regulating migration of non-neuronal cells such as epithelial cells
  • role in determining and stabilizing dentritic shape during neuron development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • neurosteroid pregnenolone (PREG)
    • protein
  • calmodulin
  • neurosteroid receptor
  • apolipoprotein E3 (APOE3)
  • non-receptor tyrosine kinase Fyn
  • growth factor receptor-bound protein 2(GRB2)
  • MAP/microtubule affinity-regulating kinase 4 (MARK4)
  • Myosin VIIA
  • Plectin and IFAP-300K
  • RII subunit of cAMP-dependent protein kinase
    • cell & other
  • binding to microtubule
    • REGULATION
    Other regulated predominantly dependent upon phosphorylation
    phosphorylated by MARK4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    age-down regulated in the frontal cortex
    Susceptibility
    Variant & Polymorphism
    Candidate gene for autism and Rett-like syndrome
    Marker
  • CALB2 and MAP2 are useful diagnostic markers for diagnosing Hirschsprung disease in rectal suction biopsies
    • Therapy target
    ANIMAL & CELL MODELS