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FLASH GENE
Symbol MAP2 contributors: shn/npt - updated : 12-10-2009
HGNC name microtubule-associated protein 2
HGNC id 6839
Location 2q34      Physical location : 210.288.770 - 210.598.834
Synonym symbol(s) MAP2A, MAP2B, MAP2C, DKFZp686I2148
DNA
TYPE functioning gene
STRUCTURE 310.06 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D2S2178 - D2S2274 - MAP2 - D2S322 - D2S157 - tel
RNA
TRANSCRIPTS type messenger
text 39 potentially differents transcripts in two groups, high molecular weight, low molecular weight, at least eight isoforms with three of form repeats of MTBD
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 splicing 9445 199.6 1827 nervous system, mostly in dendrites Shafit-Zagardo, Liu (2008)
  • containing exons 9, 10 and 11 but lacking exon 16
  • overexpresed in oral cancer with metastases
  • 12 splicing 5377 - 471 nervous system, mostly in dendrites Shafit-Zagardo, Liu (2008)
    lacking exons 9, 10, 11 and 16
    13 splicing 5470 - 502 nervous system, mostly in dendrites Shafit-Zagardo, Liu (2008)
    containing exon 16 but lacking exons 9, 10 and 11
    15 - 5844 70 559 nervous system, mostly in dendrites Liu (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineneuroendocrinepituitary  highly
     pancreas    
    Nervousbrain   highly
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text oligodendrocytes during process extension and myelination, minimally, in normal mature CNS
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three or four copies of a 18 AA repeat
  • the microtubule-binding domain in the C terminal region
  • four TAU/MAP repeats
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to Map2, Rattus norvegicus
    ortholog to Mtap2, Mus musculus
    ortholog to MAP2, Pan troglodytes
    Homologene
    FAMILY
  • MAP (mitogen activated protein) kinase family
  • microtubule-associated protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text axons, dendrites, cell bodies
    basic FUNCTION
  • maintenance of neuronal morphology by regulating the spacing of microtubules
  • involved in microtubule assembly a crucial step in neurogenesis
  • linking microtubules to other elements of the cytoskeleton
  • playing a role in microtubule stabilization
  • playing a role primarily in neurite outgrowth during neuronal development
  • may function in regulating migration of non-neuronal cells such as epithelial cells
  • role in determining and stabilizing dentritic shape during neuron development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • neurosteroid pregnenolone (PREG)
  • protein
  • calmodulin
  • neurosteroid receptor
  • apolipoprotein E3 (APOE3)
  • non-receptor tyrosine kinase Fyn
  • growth factor receptor-bound protein 2(GRB2)
  • MAP/microtubule affinity-regulating kinase 4 (MARK4)
  • Myosin VIIA
  • Plectin and IFAP-300K
  • RII subunit of cAMP-dependent protein kinase
  • cell & other
  • binding to microtubule
  • REGULATION
    Other regulated predominantly dependent upon phosphorylation
    phosphorylated by MARK4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    age-down regulated in the frontal cortex
    Susceptibility
    Variant & Polymorphism
    Candidate gene for autism and Rett-like syndrome
    Marker
  • CALB2 and MAP2 are useful diagnostic markers for diagnosing Hirschsprung disease in rectal suction biopsies
  • Therapy target
    ANIMAL & CELL MODELS