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FLASH GENE

Symbol

COL4A3

contributors: mct/npt - updated : 05-01-2010

HGNC name	collagen, type IV, alpha 3 (Goodpasture antigen)
HGNC id	2204

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	meshwork forming collagen with a GLy-X-Y repeat sequence interspersed by small interruptions
	non collagenous I domain (NC1), tumstatin, endogenous inhibitor of pathological angiogenesis and suppressing tumor growth
	C terminal peptide seqence inhibiting melanoma cell proliferation

HOMOLOGY

interspecies

homolog to murine Col4a3

Homologene

FAMILY

type IV collagen family

CATEGORY

structural protein , tumor suppressor

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix protein of glomerular basement membrane, Bowman capsule, distal TBM, neuromuscular junction

basic FUNCTION	functioning as an endothelial cell-specific inhibitor of protein synthesis
	inhibiting angiogenesis and tumor growth
	formation of basement membranes
	functioning as an endogenous inhibitor of pathological angiogenesis and a novel suppressor of proliferating endothelial cells and growth of tumors

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

sensory transduction/hearing

a component

INTERACTION

DNA

RNA

small molecule

protein

binding ITGAV beta 3 (to the inhibition of CAP-dependent translation and protein synthesis)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ATS2 , FBH , ATS3

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS