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FLASH GENE
Symbol COL4A3 contributors: mct/npt - updated : 05-01-2010
HGNC name collagen, type IV, alpha 3 (Goodpasture antigen)
HGNC id 2204
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumearinnercochlea  
Urinarykidneynephronrenal capsuleglomerulus 
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryalveoli
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text in the dermo-epidermal junction during fetal skin development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • meshwork forming collagen with a GLy-X-Y repeat sequence interspersed by small interruptions
  • non collagenous I domain (NC1), tumstatin, endogenous inhibitor of pathological angiogenesis and suppressing tumor growth
  • C terminal peptide seqence inhibiting melanoma cell proliferation
    • HOMOLOGY
    interspecies homolog to murine Col4a3
    Homologene
    FAMILY
  • type IV collagen family
    • CATEGORY structural protein , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix protein of glomerular basement membrane, Bowman capsule, distal TBM, neuromuscular junction
    basic FUNCTION
  • functioning as an endothelial cell-specific inhibitor of protein synthesis
  • inhibiting angiogenesis and tumor growth
  • formation of basement membranes
  • functioning as an endogenous inhibitor of pathological angiogenesis and a novel suppressor of proliferating endothelial cells and growth of tumors
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding ITGAV beta 3 (to the inhibition of CAP-dependent translation and protein synthesis)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ATS2 , FBH , ATS3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS